상아질 접착에 대한 matrix metalloproteinase (MMP)의 영향과 이를 극복하기 위한 전략
Effects of matrix metallproteinases on dentin bonding and strategies to increase durability of dentin adhesion
이정현, 장주혜, 손호현,
소속 상세정보
이정현 ( Lee Jung-Hyun ) - 서울대학교 치의학대학원 치과보존학교실
장주혜 ( Chang Ju-Hea ) - 서울대학교 치과병원 장애인구강진료실
손호현 ( Son Ho-Hyun ) - 서울대학교 치의학대학원 치과보존학교실
KMID : 0362320120370010002
Abstract
The limited durability of resin-dentin bonds severely compromises the longevity of composite resin restorations. Resin-dentin bond degradation might occur via degradation of water-rich and resin sparse collagen matrices by host-derived matrix metalloproteinases (MMPs). This review article provides overview of current knowledge of the role of MMPs in dentin matrix degradation and four experimental strategies for extending the longevity of resin-dentin bonds. They include: (1) the use of broad-spectrum inhibitors of MMPs, (2) the use of cross-linking agents for silencing the activities of MMPs, (3) ethanol wet-bonding with hydrophobic resin, (4) biomimetic remineralization of water-filled collagen matrix. A combination of these strategies will be able to overcome the limitations in resin-dentin adhesion.
키워드
Biomimetic remineralization; Chlorhexidine; Cross-linking agent; Dentin bonding; Ethanol wet-bonding; Matrix metalloproteinase
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